Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 32, Issue 6, Pages 351-366Publisher
CELL PRESS
DOI: 10.1016/j.tem.2021.03.002
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- National Health and Medical Research Council (NHMRC) , Australia
- University of Queensland
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This review focuses on the metabolic role of MCFAs in modulating cellular signaling and regulating key circulating metabolites and hormones, as well as the potential of MCFAs in treating various metabolic diseases in a clinical setting.
Medium-chain fatty acids (MCFAs) serve not only as an energy source but also regulate glucose and lipid metabolism. The unique transport and rapid metabolism of MCFAs provide additional clinical benefits over other substrates such as long-chain fatty acids (LCFAs) and have prompted interest in the use of MCFAs for treating metabolic and neurological disorders. This review focuses on the metabolic role of MCFAs in modulating cellular signaling and regulating key circulating metabolites and hormones. The potential of MCFAs in treating various metabolic diseases in a clinical setting has also been analyzed.
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