PKCα: Prospects in Regulating Insulin Resistance and AD

Protein kinase C alpha (PKC?) is known to participate in various signaling pathways due to its ubiquitous and dynamic characteristics. Previous studies report that PKC? abrogates peripheral insulin resistance, and recent publications show that it takes part in regulating Alzheimer?s disease (AD). Based on evidence in the literature, we have highlighted how many of the substrates of PKC? in its signal transduction cascades are common in AD and diabetes and may have the capability to regulate both diseases simultaneously. Signaling pathways crosslinking these two diseases by PKC? have not been explored. Understanding the complexities of PKC? interactions with common molecules will deepen our understanding of its regulation of relevant pathophysiologies and, in the future, may broaden the possibility of using PKC? as a therapeutic target.

Automated summary

Protein kinase C alpha (PKCα) is involved in various signaling pathways and may play a crucial role in regulating both Alzheimer's disease and diabetes simultaneously, though the interconnection between these pathways has not been fully explored. Understanding the complexities of PKCα interactions with common molecules could provide insights into its therapeutic potential in relevant pathophysiologies.