Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks

Membraneless organelles (MLOs) present as a condensed metastable phase of different proteins and RNAs organized via liquid-liquid phase separation. Recent evidence suggests the extensive incorporation of molecular chaperones into the dynamic assembly of MLOs, where different chaperones coordinate to spatiotemporally maintain the protein homeostasis and avoid abnormal protein aggregation.

Automated summary

Membraneless organelles (MLOs) are condensed metastable phases formed by liquid-liquid phase separation of different proteins and RNAs. Recent studies indicate that molecular chaperones play a crucial role in the dynamic assembly of MLOs, coordinating to maintain protein homeostasis and prevent abnormal protein aggregation.