Journal
TRENDS IN BIOTECHNOLOGY
Volume 39, Issue 6, Pages 546-549Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2020.10.007
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Most biopharmaceutical formulations currently rely on polysorbates, which are highly efficient but challenging to control in terms of quality and stability. However, alternatives such as poloxamers, albumin, and cyclodextrin are gaining popularity for their potential to protect biopharmaceuticals against physical and mechanical stresses.
Most biopharmaceutical formulations use polysorbates: surfactants that are highly efficient but difficult to manage in terms of compositional variability, quality, and stability. Alternatives, such as poloxamers, albumin, and cyclodextrin, are becoming popular and are being explored for their potential to protect biopharmaceuticals against physical and mechanical stresses.
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