Protein Amyloid Cofactors: Charged Side-Chain Arrays Meet Their Match?

Recent advances in high-resolution structural studies of protein amyloids have revealed parallel in-register cross-beta-sheets with periodic arrays of closely spaced identical residues. What do these structures tell us about the mechanisms of action of common amyloid-promoting factors, such as heparan sulfate (HS), nucleic acids, polyphosphates, anionic phospholipids, and acidic pH?

Automated summary

Recent high-resolution structural studies have revealed parallel in-register cross-beta-sheets with periodic arrays of closely spaced identical residues in protein amyloids, shedding light on the mechanisms of common amyloid-promoting factors.