Coupling lipid synthesis with nuclear envelope remodeling

The nuclear envelope (NE) is a protective barrier to the genome, yet its membranes undergo highly dynamic remodeling processes that are necessary for cell growth and maintenance. While mechanisms by which proteins promote NE remodeling are emerging, the types of bilayer lipids and the lipid-protein interactions that define and sculpt nuclear membranes remain elusive. The NE is continuous with the endoplasmic reticulum (ER) and recent evidence suggests that lipids produced in the ER are harnessed to remodel nuclear membranes. In this review, we examine new roles for lipid species made proximally within the ER and locally at the NE to control NE dynamics. We further explore how the biosynthesis of lipids coordinates NE remodeling to ensure genome protection.

Automated summary

The nuclear envelope serves as a protective barrier for the cell's genome, undergoing dynamic remodeling processes essential for cell growth and maintenance. Recent studies have shown that lipids produced in the endoplasmic reticulum are utilized to remodel nuclear membranes, with lipid species and lipid-protein interactions playing crucial roles in controlling nuclear envelope dynamics. Coordination of lipid biosynthesis is important for ensuring genome protection through nuclear envelope remodeling.