Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 141, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2021.116294
Keywords
QSRRs; Similarity; Accuracy; Biological activity; Chromatographic separation
Categories
Funding
- Torun Center of Excellence Towards Personalized Medicineoperating under Excellence Initiative-Research University
Ask authors/readers for more resources
Quantitative structure-retention relationships (QSRRs) have made significant progress in applications to chromatographic separations, with improved statistical significance and prediction accuracy, as well as expanding to identification of proteins and metabolites. Future development may prompt researchers to consider how to achieve industrial-scale application of QSRR models.
Quantitative structure-retention relationships (QSRRs) have found numerous applications in analytical science. Since first adaptation of linear free energy relationships for process of chromatographic separation, the significant progress in development of QSRR models has been achieved. Models gained statistical significance and improved values of prediction accuracy as well as started to be applied for identification of proteins, metabolites in non-targeted analysis and determination of relative biological activities of solutes. The ongoing progress of development of QSRR models for different chromatographic systems may lead researchers to the reasonable question: how far are we from industrial scale application of QSRRs? The current review paper is aimed to discuss crucial points, achievements and recent advances, future perspectives in QSRR applications to reflect on this question. (c) 2021 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available