Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 139, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2021.116257
Keywords
G-quadruplex; DNAzyme; Amplification; Biosensing; Bioimaging; Cancer therapy
Categories
Funding
- National Natural Science Foundation of China [21205142]
- State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University [2017006]
- Research Innovation Program for Graduates of Central South University [2018zzts384, 2019zzts453]
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G-quadruplex is a three-dimensional secondary structure of nucleic acids formed by Hoogsteen hydrogen pairing of four guanines, with various topologies applicable in biosensing and bioimaging. By incorporating fluorescence dyes or forming HRP-mimicking DNAzyme, G-quadruplex-based biosensors enable sensitive and selective detection of a wide range of molecules, thereby contributing to cancer therapy.
G-quadruplex is a three-dimensional secondary structure of nucleic acids formed by the Hoogsteen hydrogen pairing of four guanines. Diverse topologies of G-quadruplex could be employed in biosensing and bioimaging. By intercalating fluorescence dyes into G-quadruplex or forming a horseradish peroxidase (HRP)-mimicking G-quadruplex/hemin DNAzyme, G-quadruplexes based biosensors realized the sensitive and selective detection of nucleic acids, protein, enzyme activity, ions, small molecules, exosomes, cells, and microorganisms. The vital role that cellular G-quadruplexes played in genome further facilitated the application of G-quadruplex stabilizing on cancer therapy. Combined with G-quadruplex aptamer, which is an efficient therapeutic tool, a current landscape of the application potential of this fascinate nucleic acids structure from clinical diagnosis to cancer therapy is summarized here. (C) 2021 Elsevier B.V. All rights reserved.
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