Journal
TOXIN REVIEWS
Volume 41, Issue 4, Pages 1290-1303Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15569543.2021.1966637
Keywords
Herbicide; atrazine; neurotoxicity; reproductive toxicity; spermatogenesis
Categories
Funding
- Mashhad University of Medical Sciences, Mashhad, Iran
- Italian Ministry of health-Ricercar Corrente to IRCCS Multimedica
Ask authors/readers for more resources
Atrazine, a common herbicide, has detrimental effects on cells and can pass through biological barriers. Studies have discussed its harmful impacts on various parts of the brain and the reproductive system.
Atrazine is one of the common herbicides with an annual usage of 70,000-90,000 tons worldwide. Due to its long half-life (>60 days), atrazine persists in water and soil for long-term periods. This herbicide induces oxidative stress, inflammation, mitochondrial dysfunction and apoptosis in the exposed cells. It also passes the biological barriers, such as the blood-brain barrier and the blood-testis barrier. This review discusses, in detail, atrazine's detrimental effects on the different parts of the brain, including the cerebral cortex, hippocampus, substantia nigra, striatum, and cerebellum. Moreover, the current knowledge regarding the atrazine's effects on the reproductive system is also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available