Journal
THROMBOSIS AND HAEMOSTASIS
Volume 122, Issue 1, Pages 8-19Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1562-7599
Keywords
viral hemorrhagic fever; COVID-19; anticoagulation; disseminated intravascular coagulation; endothelial cells
Categories
Funding
- Ministry of Health, Labor, and Welfare of Japan
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
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Several viral infectious diseases emerging or re-emerging from wildlife vectors pose serious threats to global health, with increased international travel and climate change exacerbating the risk. The COVID-19 pandemic serves as a significant example of the worldwide spread, emphasizing the need to prepare for future pandemics of life-threatening viral diseases.
Several viral infectious diseases have emerged or re-emerged from wildlife vectors that have generated serious threats to global health. Increased international travel and commerce increase the risk of transmission of viral or other infectious diseases. In addition, recent climate changes accelerate the potential spread of domestic disease. The coronavirus disease 2019 (COVID-19) pandemic is an important example of the worldwide spread, and the current epidemic will unlikely be the last. Viral hemorrhagic fevers, such as dengue and Lassa fevers, may also have the potential to spread worldwide with a significant impact on public health with unpredictable timing. Based on the important lessons learned from COVID-19, it would be prudent to prepare for future pandemics of life-threatening viral diseases. The key concept that connect COVID-19 and viral hemorrhagic fever is the coagulation disorder. This review focuses on the coagulopathy of acute viral infections since hypercoagulability has been a major challenge in COVID-19, but represents a different presentation compared with viral hemorrhagic fever. However, both thrombosis and hemorrhage are understood as the result of thromboinflammation due to viral infections, and the role of anticoagulation is important to consider.
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