Journal
THORAX
Volume 77, Issue 2, Pages 191-195Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2020-216153
Keywords
tobacco and the lung
Categories
Funding
- Leibniz Competition 2016, 'The lung microbiota at the interface between airway epithelium and environment'
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This study reveals distinct bacterial response patterns in the upper and lower respiratory tract to cigarette smoking, leading to a higher abundance of opportunistic pathogens. The clinical significance of these dysbioses for health needs further exploration.
To examine the role of smoking on the bacterial community composition of the upper and the lower respiratory tract, a monocentric, controlled prospective study was performed, including healthy smokers, ex-smokers and never-smokers. Smokers were further grouped according to their smoking history. Bacterial diversity was analysed using a molecular barcoding approach based on directly extracted DNA. Our study shows for the first time distinct bacterial response patterns in the upper and lower respiratory tract to cigarette smoking leading to a higher abundance of opportunistic pathogens. The clinical significance of these dysbioses for health needs to be further explored.
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