Journal
THEORETICAL POPULATION BIOLOGY
Volume 139, Issue -, Pages 1-17Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.tpb.2021.03.003
Keywords
Nearly-neutral theory; Mutation-selection-drift equilibrium; Moran model; McDonald-Kreitman test; Linear and quadratic selection; Mutation bias
Funding
- Austrian Science Fund (FWF) [DK W1225-B20]
- Vienna Science and Technology Fund (WWTF), Austria [MA016-061]
- School of Biology at the University of St.Andrews
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This article analyzes a biallelic reversible mutation model with linear and quadratic selection, which can lead to patterns of polymorphism and substitution rates. By using a boundary-mutation Moran model, the equilibrium distribution for polymorphic and monomorphic variants in populations is derived.
In this article, a biallelic reversible mutation model with linear and quadratic selection is analysed. The approach reconnects to one proposed by Kimura (1979), who starts from a diffusion model and derives its equilibrium distribution up to a constant. We use a boundary-mutation Moran model, which approximates a general mutation model for small effective mutation rates, and derive its equilibrium distribution for polymorphic and monomorphic variants in small to moderately sized populations. Using this model, we show that biased mutation rates and linear selection alone can cause patterns of polymorphism within and substitution rates between populations that are usually ascribed to balancing or overdominant selection. We illustrate this using a data set of short introns and fourfold degenerate sites from Drosophila simulans and Drosophila melanogaster. (C) 2021 The Author(s). Published by Elsevier Inc.
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