Journal
TETRAHEDRON LETTERS
Volume 78, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2021.153292
Keywords
Colchicine; Meldrum's acid; Arylglyoxals; Multicomponent reactions; Telescoped processes
Categories
Ask authors/readers for more resources
A one-pot approach was developed for the synthesis of substituted colchicine derivatives based on the telescoped multicomponent reaction of colchiceine, arylglyoxals, and Meldrum's acid. The regiospecific formation of a distinctive moiety is a key feature of this method. Advantages include the use of readily accessible starting materials, process simplicity, and easy isolation of the target products.
A straightforward one-pot approach was developed for the synthesis of substituted colchicine derivatives based on the telescoped multicomponent reaction of colchiceine, arylglyoxals and Meldrum's acid. Regiospecific formation of the 6,7-dihydrobenzo[9,10]heptaleno[3,2-b]furan-9(5H)-one moiety is a distinctive feature of the protocol. Advantages of this method include the use of readily accessible starting materials, process simplicity and easy isolation of the target products. The structure of one of the furotropolone derivatives was confirmed by 2D NMR-spectroscopy. (c) 2021 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available