Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach

A rapid synthesis of the core structures of crinane and haemanthamine has been developed, enabled by a multicomponent approach. This work constitutes a formal synthesis of crinane and sets the stage for access to both families of natural products and key analogues. A key highlight of the approach is the modularity of the core synthesis, overcoming existing challenges for these scaffolds and providing a path to explore site-selective oxidation to expand the scope of molecules accessible from common intermediates. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

A rapid synthesis approach has been developed for the core structures of crinane and haemanthamine using a multicomponent method. The modularity of core synthesis in this work overcomes existing challenges and provides a pathway for exploring site-selective oxidation to expand the range of accessible molecules.