Journal
TETRAHEDRON
Volume 97, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2021.132276
Keywords
One-step synthesis; DFT; Lactic acid; Oxazolo[3; 2-c] pyrimidine
Categories
Funding
- Hainan Provincial Natural Science Foundation of P.R. China [218MS005]
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A new method for one-step synthesis of oxazolo [3,2-c] pyrimidine core and its derivatives has been developed in inexpensive and green bio-based solvent lactic acid without any additional catalysts. Density functional theory calculations located the reaction pathway and identified the intermolecular nucleophilic addition step to be the rate-limiting step, resulting in the synthesis of twenty new oxazolo [3,2-c] pyrimidine derivatives.
A new method for one-step synthesis of oxazolo[3,2-c] pyrimidine core and its derivatives has been developed in inexpensive and green bio-based solvent lactic acid without any additional catalysts and additives. Density functional theory calculations located the reaction pathway and identified the intermolecular nucleophilic addition step to be the rate-limiting step. By this method, twenty new oxazolo [3,2-c] pyrimidine derivatives were synthesized in high yield and characterized by spectroscopic analysis and X-ray diffraction. (c) 2021 Published by Elsevier Ltd.
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