Selective C-alkylation of substituted naphthols under non-aqueous conditions

A simple and selective C-alkylation of 1-and 2-naphthols with benzylic and allylic halides was developed. In an organic solvent, like cyclopentyl methyl ether, or toluene in the presence of the ether or alcohol additives, a selective ortho-addition leading to substituted naphthalenones up to 90 % was achieved. (c) 2021 Published by Elsevier Ltd.

Automated summary

A simple and selective C-alkylation of 1- and 2-naphthols with benzylic and allylic halides was developed, achieving a selective ortho-addition with high yields up to 90% in the presence of organic solvents and additives.