Journal
TALANTA
Volume 230, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2021.122351
Keywords
Glow-type; Chemiluminescence; Luminol; Guanosine; Hydrogel
Categories
Funding
- National Natural Science Foundation of China [22034006, 21721003, 21627808]
- National Key Re-search and Development Program of China [2016YFA0201301]
- Key Research Pro-gram of Frontier Sciences, CAS [QYZDY-SSWSLH019]
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This paper presents an intensive and glow-type chemiluminescence hydrogel prepared by incorporating luminol and hemin into the scaffold of guanosine-derived hydrogel. The hydrogel exhibits significant enzyme-like activity to H2O2 and can emit blue light visible to the naked eye for over 8 hours. The lasting-time CL emission is achieved through slow-diffusion-controlled heterogeneous catalysis mechanism, showing promising application in cold light source and H2O2 detection in real biological samples.
In this paper, an intensive and glow-type chemiluminescence (CL) hydrogel was prepared by simultaneous incorporation of chemiluminescence reagent (luminol) and catalytic cofactor (hemin) into the scaffold of guanosine-derived hydrogel. The self-assembled hydrogel consisted of K+ stabilized hemin/G-quartet structures, showing significant enzyme-like activity to H2O2-mediated oxidation of luminol. After adding H2O2 into the hydrogel, blue light visible to naked eyes would come into being and last for over 8 h. The lasting-time CL emission of hydrogel was achieved due to a mechanism of slow-diffusion-controlled heterogeneous catalysis. Moreover, this self-assembled hydrogel performed a good response to H2O2 and the CL emission images could be recorded by smartphone. The hydrogel could remain excellent lifetime stability for months and the stable, enhanced and glow-type CL emission could improve the reliability and precision of CL detection, which has a promising application in cold light source and H2O2 detection of real biological samples.
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