Serum cystatin C or cystatin C-based glomerular filtration rate may be a better choice in estimating renal function in women with preeclampsia

Editorial Material Medicine, General & Internal

The predictors of sepsis-related acute kidney injury

Wen-Ling Lee et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2021)

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Letter Medicine, General & Internal

Can the simple parameter of peripheral hematological examination predict the outcome in patients with septic acute kidney injury?

Fa-Kung Lee et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2021)

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Article Obstetrics & Gynecology

Taiwanese new direction in prediction of early pregnancy preeclampsia

Yen-Tin Chen et al.

Summary: The study evaluated the performance of first trimester screening for preeclampsia in Taiwan, demonstrating a high detection rate using the FMF model. Integration of preeclampsia and Down screening could establish a one-step workflow.

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2021)

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Article Medicine, General & Internal

Comprehensive analysis of gene expression and DNA methylation for preeclampsia progression

Jianrong Wang et al.

Summary: This study identified valuable biomarkers associated with preeclampsia (PE), such as OCA2, CDK2AP1, and ADAM12, through integrated analysis of gene expression and DNA methylation datasets. Functional analysis revealed cell adhesion molecules and leukocyte transendothelial migration as important pathways in PE. Methylation validation experiments confirmed differentially methylated sites and their effects on gene expression in PE samples compared to normal samples.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2021)

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Article Medical Laboratory Technology

Comparison of cystatin C-based and creatinine-based glomerular filtration rate in the prediction of postoperative residual hypertension in aldosterone-producing adenoma patients after adrenalectomy

Ching-Way Chen et al.

Summary: Renal function is associated with postoperative residual hypertension in APA patients. A combination of creatinine and cystatin C-based GFR estimation method is more accurate in predicting postoperative hypertension in these patients.

CLINICA CHIMICA ACTA (2021)

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Letter Medicine, General & Internal

The use of serum level of microRNA-485-5P in prediction of renal function in lupus nephritis patients

Wen-Hsun Chang et al.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2021)

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Review Medicine, General & Internal

Pre-eclampsia

Lucy C. Chappell et al.

Summary: Pre-eclampsia is a pregnancy disorder characterized by placental malperfusion, leading to hypertension and multi-organ injury, with potential fetal growth restriction and stillbirth. While prophylactic low-dose aspirin can reduce the risk of preterm pre-eclampsia, there are currently no curative treatments once pre-eclampsia is diagnosed except for delivery. Ongoing studies are evaluating various strategies and drugs to prevent and manage pre-eclampsia.

LANCET (2021)

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Article Obstetrics & Gynecology

The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia

Aysun Tekeli Taskomur et al.

Summary: The study compared the diagnostic efficiency of cystatin C with traditional kidney markers in preeclampsia and analyzed their relationship with neutrophil-lymphocyte and platelet-lymphocyte ratios. The results showed that cystatin C level reflects renal functions better than uric acid and creatinine in preeclampsia, and it can be used as a prognostic marker in preeclamptic pregnancies. Neutrophil-lymphocyte ratio levels may be a parameter correlating with severity in severe preeclampsia.

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2021)

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Article Pharmacology & Pharmacy

Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice

Seo-Kyoung Hwang et al.

Summary: A new in- and ex vivo hybrid method for measuring GFR using the in vivo imaging system (IVIS) was developed as an alternative to the traditional filtration marker method with fluorescence molecular tomography (FMT). The results showed that the IVIS imaging measurement of inulin clearance in untreated, vehicle-treated and cyclosporine A-treated mice yielded comparable GFR values to those obtained with FMT imaging, demonstrating the feasibility and reliability of this alternative technique for assessing renal function in pharmacological and toxicological studies.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2021)

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Review Obstetrics & Gynecology