A Novel Pseudo-Three-Component Synthetic Strategy for the Synthesis of 1,6-Dihydroazaazulenes via Cyclization of Pyrrolyl-enones

A synthetic novel strategy involving a pseudo-three-component reaction to obtain 1,6-dihydroazaazulenes derivates via cyclization of pyrrolyl-enones was developed. This reaction is carried out under mild conditions from simple starting materials and catalyzed with ionic liquid. Notably, three new C-C bonds are formed in the one-pot process. The target molecules are of interest in medicinal chemistry as they contain a privileged scaffold and are considered indole homologues.

Automated summary

A novel synthetic strategy was developed to obtain 1,6-dihydroazaazulenes derivates through a pseudo-three-component reaction involving cyclization of pyrrolyl-enones. The reaction is efficient, forming three new C-C bonds under mild conditions, and the resulting molecules are considered important in medicinal chemistry.