Journal
SURFACE & COATINGS TECHNOLOGY
Volume 416, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.surfcoat.2021.127177
Keywords
Degradation; Nanopore; Calcium fluoride; Hydroxyapatite; Cell proliferation
Funding
- Intergovernmental Cooperation Projects in the National Key Research and Development Plan of the Ministry of Science and Technology of the People's Republic of China [2016YFE0111800]
- Nanjing University of Science & Technology Independent Research Project [30919013301]
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The F-HA coating, forming a nanopore structure through ion exchange in simulated body fluid, can accelerate apatite-like deposition, enhance corrosion resistance, and promote cell proliferation.
The surface properties of bone tissue engineered scaffolds are essential for cell attachment, proliferation, and differentiation. Calcium fluoride-doped hydroxyapatite (F-HA) coating prepared by pulsed laser deposition can rapidly form a nanopore structure through ion exchange in the simulated body fluid. Results showed that F-HA coating can accelerate the apatite-like deposition and improve the corrosion resistance of the coating. Results also revealed that F-HA coating can promote cell proliferation (p < 0.05). Briefly, F- HA coating can mimic the porous structure of natural bones and be for surface modification of bone tissue engineered scaffolds, so as to promote new bone growth.
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