Journal
GASTROENTEROLOGY
Volume 150, Issue 1, Pages 82-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2015.09.011
Keywords
Antiviral; Chronic Hepatitis; Immunosuppression; Polymerase Inhibitor
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Funding
- Swiss National Science Foundation [31003A-138484, 31003A-156030]
- Interuniversity Attraction Poles Programme of the Belgian Federal Science Policy Office
- KU Leuven Geconcerteerde Onderzoeksacties
- Starr Foundation
- Deutsche Forschungsgemeinschaft
- Robertson Foundation
- Research Foundation Flanders
- Bristol-Myers Squibb at The Rockefeller University
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Infection with hepatitis E virus genotype 3 may result in chronic hepatitis in immunocompromised patients. Reduction of immunosuppression or treatment with ribavirin or pegylated interferon-alpha can result in viral clearance. However, safer and more effective treatment options are needed. Here, we show that sofosbuvir inhibits the replication of hepatitis E virus genotype 3 both in subgenomic replicon systems as well as a full-length infectious clone. Moreover, the combination of sofosbuvir and ribavirin results in an additive antiviral effect. Sofosbuvir may be considered as an add-on therapy to ribavirin for the treatment of chronic hepatitis E in immunocompromised patients.
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