Journal
SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
Volume 182, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.sab.2021.106234
Keywords
Nail; Total reflection X-ray fluorescence; Elemental analysis; Colorectal cancer
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Funding
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [103.042017.311]
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TXRF technique was used to analyze elements in nails of 62 subjects, revealing significant differences in concentrations of elements Ca, Cr, Fe, Cu, Zn, As, and Se between men with colon cancer and normal subjects. These elements could be potential factors for diagnosing colon cancer risk in men.
Sixty-two subjects (31 men with colon cancer) participated in this study. The analysis of elements in the nails was performed by total reflection X-ray fluorescence (TXRF) technique. The results showed that fifteen elements were quantified, including the following: S, P, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, and Br. We have found that there were significant differences in the concentrations of elements Ca, Cr, Fe, Cu, Zn, As, and Se between normal subjects and men with colon cancer (p < 0.05). We conclude that TXRF is a technique suitable for elemental analysis in human nail samples. The concentration of elements Ca, Cr, Fe, Cu, Zn, As, and Se could be among the factors used for the diagnosis of colon cancer risk in men.
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