Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 256, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2021.119735
Keywords
Twisted intramolecular charge transfer (TICT); Aggregation-induced emission (AIE); Fluorescent probe; Hypochlorite; Ultrafast response
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Funding
- Application and Fundamental Research Project of Shanxi Province [201801D121270]
- National Natural Science Foundation of China [21571117, 21575083]
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A fluorescent probe TPB-CN was designed and synthesized for fast and efficient detection of ClO-, with successful application in living cells and mice.
Hypochlorite (HClO/ClO-), an important reactive oxygen species (ROS), plays a significant role in the human immune system. Thus, developing a fast and efficient method for detecting ClO- is quite neces-sary. Herein, we designed and synthesized a fluorescent probe TPB-CN based on twisted intramolecular charge transfer (TICT) and aggregation-induced emission (AIE) characteristics. The probe could respond to ClO- with an ultrafast response velocity (<2 s). The detection limit was calculated to be 6.198 nM. In addition, probe TPB-CN was successfully applied for detecting ClO- in living cells and mouse. (C) 2021 Elsevier B.V. All rights reserved.
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