Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 257, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2021.119799
Keywords
Surface-enhanced Raman spectroscopy; Chemical adsorption; Fenbendazole
Categories
Funding
- National Natural Science Foundation of China [61575030]
- Natural Science Foundation of Jilin province [20180101283JC, 0200301042RQ]
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This study investigated the chemical adsorption of fenbendazole and gold nanoparticles, explaining the differences between theoretical and experimental Raman spectra and identifying enhanced signals at specific frequencies. The experimental results suggest that fenbendazole is vertically adsorbed on the surface of gold nanoparticles through imidazole.
Fenbendazole, a benzimidazole derivative with anti-tubulin polymerization properties, has been widely used in the treatment of parasitic infections. Because of its anticancer activity similar to that of many anticancer drugs, low cost and few side effects, fenbendazole has attracted wide research attention. The chemical adsorption of fenbendazole and gold nanoparticles are studied by the UV-Vis spectrophotometry, density functional method, Raman spectroscopy and surface-enhanced Raman spectroscopy. By comparing and analyzing the theoretical and experimental Raman spectra, this paper explains the reasons for the difference between the theoretical and experimental Raman spectra. Meanwhile, it is also found that the frequencies at 851 cm(-1), 1222 cm(-1), 1425 cm(-1) and 1566 cm(-1) are greatly enhanced. It is found that imidazole is adsorbed vertically to the surface of the substrate. It is concluded that Fenbendazole is vertically adsorbed on the surface of AuNPs through imidazole. (C) 2021 Elsevier B.V. All rights reserved.
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