Journal
GASTROENTEROLOGY
Volume 150, Issue 6, Pages 1280-1291Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2016.02.018
Keywords
Sensory Physiology; Enteric Nervous System; Neuroimmune Signaling; Mucosal Barrier Function
Categories
Funding
- NIDDK NIH HHS [R01 DK083418, R01 DK062267] Funding Source: Medline
- BLRD VA [IK6 BX003610, I01 BX002188] Funding Source: Medline
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This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled Rome IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs, and new areas for future research into their pathophysiology.
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