Journal
GASTROENTEROLOGY
Volume 151, Issue 4, Pages 633-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2016.06.025
Keywords
IFN-free; DAA; SVR; Viral Persistence
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Funding
- Instituto de Salud Carlos III, Ministerio de Economia y Competitividad - Fondo Europeo de Desarrollo Regional, Union Europea, Una manera de hacer Europa [PI11/01907, PI13/00155]
- Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement [2014_SGR_605]
- Instituto de Salud Carlos III
- EASL
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We assessed the presence of hepatitis C virus (HCV) RNA in liver explants from 39 patients awaiting liver transplantation who were treated with an interferon-free regimen and had undetectable serum HCV RNA at the time of liver transplantation. Interestingly, HCV RNA was detected in most liver explants (67%). Patients with HCV RNA-positive explants had received shorter courses of treatment, and HCV RNA was undetectable in serum for shorter periods before transplantation compared to patients with HCV RNA-negative explants (P =.014 and P=. 013, respectively). Levels of HCV RNA in explants were significantly higher in patients with a relapse of HCV infection than patients who responded to treatment (P =.016), but most patients (85%) with residual HCV-RNA in the explant achieved a sustained virologic response after receiving their liver transplant.
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