Journal
SMALL
Volume 17, Issue 41, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202103252
Keywords
catalytic therapy; NIR-II biowindow; NIR-II PA; NIR-II FL imaging; NIR-II photothermal therapy; zeolite-carbon-based nanozymes
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Funding
- National Natural Science Foundation of China [82071987, 81771907, 81802440]
- Science and Technology Innovation Team Project of Shanxi Province [201705D131026]
- Engineering Technology Research Center of Shanxi Province [201805D121008]
- Scientific and Technological Achievements Transformation Project of Shanxi Province [201704D131006]
- Laboratory Construction Project of Shanxi Province
- Projects for Local Science and Technology Development Guided by the Central Committee [YDZX20191400002537]
- Shanxi Scholarship Council of China [2020-177]
- Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province [20200006]
- Four Batches Innovation Team of Science and Technology Medicine Innovation Plan [2020TD11]
- Four Batches Key Laboratory of Science and Technology Medicine Innovation Program [2020SYS15]
- Four Batches Science and Technology Medicine Innovation Project [2020XM10]
- Shanxi Nanobiomedical Engineering Research Center, Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019L0415]
- Shanxi Province Science Foundation for Youths [201801D221400, 201901D211343]
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This study introduces a novel nanozyme HSC-2 with excellent dual-mode NIR-II PA/NIR-II FL imaging performance for precise photothermal-catalytic synergistic therapy. Through optimizing the silicon-to-carbon ratio, HSC-2 achieves efficient tumor photothermal therapy in the NIR-II window and exhibits remarkable synergistic therapeutic effects in the tumor microenvironment.
In the second near-infrared (NIR-II) biowindow, multimodal optical imaging-guided precise antitumor therapy is a novel strategy for high-efficiency tumor theranostics, however, the all-in-one dual NIR-II photoacoustic (NIR-II PA) and NIR-II fluorescence (NIR-II FL) nanoprobes have been rarely reported mainly due to the short of a simple and universal design approach. Herein, a NIR-II PA/NIR-II FL imaging-adjustable nanozyme (HSC-2) is designed and developed to guide precise photothermal-catalytic synergistic therapy. Based on the ionic liquids adsorption capacity, the electronic structure of zeolite nano-Beta (three dimensional 12-ring pore system and large surface area) can be turned from the indirect band gap to direct band gap via doping carbon in the framework, resulting in outstanding NIR-II FL emission characteristics. As the silicon etching reaction proceeds, HSC-2 shows superior dual-modal NIR-II PA/NIR-II FL imaging performance facilitated by the optimal silicon-to-carbon ratio, simultaneously ensuring efficient tumor photothermal therapy (PTT) in the NIR-II window. Impressively, the peroxidase-mimic activity of HSC-2 in the tumor microenvironment could be further remarkably enhanced by its photothermal effect, leading to excellent synergistic PTT/catalytic therapy. Moreover, the HSC-2 exhibits dual-enzyme activity, and its catalase-like property could effectively eliminate excessive ROS for protection of the normal cells.
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