Journal
SMALL
Volume 17, Issue 43, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202100495
Keywords
faraday current; fluorescence; ionic current; sensing; solid-state nanochannels
Categories
Funding
- Science and Technology Development Fund, Macau SAR [0114/2019/A2, 019/2017/AMJ, 0085/2020/A2]
- University of Macau [MYRG2019-00051-FHS, MYRG2017-00066-FHS]
Ask authors/readers for more resources
Inspired by bioprotein channels, this study constructs solid-state nanochannels in abiotic environments for smart sensing of various targets. The dynamic switch of surface properties through modified probes and three detection methods – transmembrane ionic current, fluorescence signals, and faraday current signals – enable effective monitoring of targets.
Inspired from bioprotein channels of living organisms, constructing abiotic analogues, solid-state nanochannels, to achieve smart sensing towards various targets, is highly seductive. When encountered with certain stimuli, dynamic switch of terminal modified probes in terms of surface charge, conformation, fluorescence property, electric potential as well as wettability can be monitored via transmembrane ionic current, fluorescence intensity, faraday current signals of nanochannels and so on. Herein, the modification methodologies of nanochannels and targets-detecting application are summarized in ions, small molecules, as well as biomolecules, and systematically reviewed are the nanochannel-based detection means including 1) by transmembrane current signals; 2) by the coordination of current- and fluorescence-dual signals; 3) by faraday current signals from nanochannel-based electrode. The coordination of current and fluorescence dual signals offers great benefits for synchronous temporal and spatial monitoring. Faraday signals enable the nanoelectrode to monitor both redox and non-redox components. Notably, by incorporation with confined effect of tip region of a needle-like nanopipette, glorious in-vivo monitoring is conferred on the nanopipette detector at high temporal-spatial resolution. In addition, some outlooks for future application in reliable practical samples analysis and leading research endeavors in the related fantastic fields are provided.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available