4.8 Review

2D MXene Nanomaterials for Versatile Biomedical Applications: Current Trends and Future Prospects

Journal

SMALL
Volume 17, Issue 46, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202100946

Keywords

biological applications; compatibility; MXenes; nanomedicines; surface modification

Funding

  1. Shenzhen Basic Research Free Exploration Project [JCYJ20180306171650007]
  2. National Natural Science Foundation of China [21905069]
  3. Shenzhen Science and Technology Innovation Committee [JCYJ20180507183907224, KQTD20170809110344233]
  4. Fund for Knowledge Innovation in Shenzhen [20180430170126680]

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Research on 2D nanomaterials, particularly 2D MXene nanomaterials, is still in its early stages. While most studies have focused on elucidating the unique properties of these materials, there is a growing interest in their biomedical applications. Recent developments have highlighted the potential of 2D MXenes in areas such as drug delivery, antibacterial activity, bioimaging, sensing, and biocompatibility, with a focus on further clinical applications for next-generation cancer treatments.
Research on 2D nanomaterials is still in its early stages. Most studies have focused on elucidating the unique properties of the materials, whereas only few reports have described the biomedical applications of 2D nanomaterials. Recently, important questions about the interaction of 2D MXene nanomaterials with biological components have been raised. 2D MXenes are monolayer atomic nanosheets derived from MAX phase ceramics. As a new type of inorganic nanosystems, they are being widely used in biology and biomedicine. This review introduces the latest developments in 2D MXenes for the most advanced biomedical applications, including preparation and surface modification strategies, treatment modes, drug delivery, antibacterial activity, bioimaging, sensing, and biocompatibility. Besides, this review also discusses the current development trends and prospects of 2D inorganic nanosheets for further clinical applications. These emerging 2D inorganic MXenes will play an important role in next-generation cancer treatments.

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