4.8 Review

A Holistic Review of the State-of-the-Art Microfluidics for Exosome Separation: An Overview of the Current Status, Existing Obstacles, and Future Outlook

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Exosome detection via the ultrafast-isolation system: EXODUS

Yuchao Chen et al.

Summary: The study introduces an ultrafast isolation system called EXODUS for efficient purification of exosomes from biofluids, with superior speed, purity, and yield compared to other isolation techniques.

NATURE METHODS (2021)

Article Biochemical Research Methods

Microfluidic-based capture and release of cancer-derived exosomes via peptide-nanowire hybrid interface

Thanawat Suwatthanarak et al.

Summary: Peptide-functionalized nanowires have been developed as an effective means to capture and release cancer-derived exosomes within a microfluidic channel. This approach significantly enhances the exosome-capturing ability of ZnO nanowires, providing a new avenue for developing microfluidic platforms for exosome-based diagnostics and therapeutics.

LAB ON A CHIP (2021)

Article Cell Biology

Purity and yield of melanoma exosomes are dependent on isolation method

Shin La Shu et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

Article Chemistry, Multidisciplinary

Oscillatory Viscoelastic Microfluidics for Efficient Focusing and Separation of Nanoscale Species

Mohammad Asghari et al.

ACS NANO (2020)

Article Biochemical Research Methods

Sequential phosphoproteomics and N-glycoproteomics of plasma-derived extracellular vesicles

Hillary Andaluz Aguilar et al.

NATURE PROTOCOLS (2020)

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Article Chemistry, Multidisciplinary

AuNP-Amplified Surface Acoustic Wave Sensor for the Quantification of Exosomes

Chenyun Wang et al.

ACS SENSORS (2020)

Article Chemistry, Analytical

Exosome Purification and Analysis Using a Facile Microfluidic Hydrodynamic Trapping Device

Mahnoush Tayebi et al.

ANALYTICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Ayuko Hoshino et al.

Review Biotechnology & Applied Microbiology

Technologies and Standardization in Research on Extracellular Vesicles

Srujan Gandham et al.

TRENDS IN BIOTECHNOLOGY (2020)

Article Biochemical Research Methods

Microfluidic Raman biochip detection of exosomes: a promising tool for prostate cancer diagnosis

Yanlin Wang et al.

LAB ON A CHIP (2020)

Article Biochemical Research Methods

Label-free ferrohydrodynamic separation of exosome-like nanoparticles

Yang Liu et al.

LAB ON A CHIP (2020)

Article Biochemical Research Methods

Microfluidic device for high-throughput affinity-based isolation of extracellular vesicles

Ting-Wen Lo et al.

LAB ON A CHIP (2020)

Review Critical Care Medicine

Neuronal Enriched Extracellular Vesicle Proteins as Biomarkers for Traumatic Brain Injury

Hanuma Kumar Karnati et al.

JOURNAL OF NEUROTRAUMA (2019)

Article Multidisciplinary Sciences

Multiplexed profiling of single-cell extracellular vesicles secretion

Yahui Ji et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemical Research Methods

Breast Cancer-Derived Exosomes Reflect the Cell-of-Origin Phenotype

Shu Wen Wen et al.

PROTEOMICS (2019)

Article Engineering, Biomedical

Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip

Peng Zhang et al.

NATURE BIOMEDICAL ENGINEERING (2019)

Article Chemistry, Multidisciplinary

Label-Free Surface Protein Profiling of Extracellular Vesicles by an Electrokinetic Sensor

Sara Cavallaro et al.

ACS SENSORS (2019)

Review Nanoscience & Nanotechnology

Acoustofluidic separation of cells and particles

Mengxi Wu et al.

MICROSYSTEMS & NANOENGINEERING (2019)

Review Chemistry, Analytical

Microfluidic strategies for label-free exosomes isolation and analysis

Wentao Su et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

Article Materials Science, Multidisciplinary

Tangential Flow Microfluidics for the Capture and Release of Nanoparticles and Extracellular Vesicles on Conventional and Ultrathin Membranes

Mehdi Dehghani et al.

ADVANCED MATERIALS TECHNOLOGIES (2019)

Article Biochemistry & Molecular Biology

Vesiclepedia 2019:a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

Mohashin Pathan et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Chemistry, Multidisciplinary

A Label-Free Platform for Identification of Exosomes from Different Sources

Zhongbo Yan et al.

ACS SENSORS (2019)

Article Chemistry, Multidisciplinary

Artificial chimeric exosomes for anti-phagocytosis and targeted cancer therapy

Kai-Long Zhang et al.

CHEMICAL SCIENCE (2019)

Article Computer Science, Information Systems

Microfluidic Approaches Toward the Isolation and Detection of Exosome Nanovesicles

Yuan Jia et al.

IEEE ACCESS (2019)

Article Medicine, Research & Experimental

Ovarian cancer cell-secreted exosomal miR-205 promotes metastasis by inducing angiogenesis

Liuqing He et al.

THERANOSTICS (2019)

Article Chemistry, Multidisciplinary

Multiplexed Profiling of Single Extracellular Vesicles

Kyungheon Lee et al.

ACS NANO (2018)

Article Chemistry, Multidisciplinary

Designer Exosomes for Active Targeted Chemo-Photothermal Synergistic Tumor Therapy

Jie Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

Article Biochemical Research Methods

Label-free extraction of extracellular vesicles using centrifugal microfluidics

Joo Chuan Yeo et al.

BIOMICROFLUIDICS (2018)

Article Biochemistry & Molecular Biology

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

Nasibeh Karimi et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Article Critical Care Medicine

Extracellular Vesicles in Lung Disease

Hiroshi Kubo

CHEST (2018)

Review Biochemical Research Methods

Recent progress of particle migration in viscoelastic fluids

Dan Yuan et al.

LAB ON A CHIP (2018)

Article Biochemical Research Methods

Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

Qingfu Zhu et al.

LAB ON A CHIP (2018)

Article Chemistry, Multidisciplinary

Single-Exosome-Counting Immunoassays for Cancer Diagnostics

Chunchen Liu et al.

NANO LETTERS (2018)

Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Fluorescent label-free quantitative detection of nano-sized bioparticles using a pillar array

Kerwin Kwek Zeming et al.

NATURE COMMUNICATIONS (2018)

Review Engineering, Biomedical

Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics

Wenshuo Wang et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Chemistry, Analytical

Magnetic-Based Microfluidic Device for On-Chip Isolation and Detection of Tumor-Derived Exosomes

Huiying Xu et al.

ANALYTICAL CHEMISTRY (2018)

Article Biophysics

Detection of exosomes by ZnO nanowires coated three-dimensional scaffold chip device

Zhen Chen et al.

BIOSENSORS & BIOELECTRONICS (2018)

Article Multidisciplinary Sciences

Interferometric plasmonic imaging and detection of single exosomes

Yuting Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Chemistry, Analytical

A simple, specific and on-off type MUC1 fluorescence aptasensor based on exosomes for detection of breast cancer

Junli Zhang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Article Medicine, Research & Experimental

Generation and testing of clinical-grade exosomes for pancreatic cancer

Mayela Mendt et al.

JCI INSIGHT (2018)

Review Nanoscience & Nanotechnology

Review: Isolation and Detection of Tumor-Derived Extracellular Vesicles

Parissa Ziaei et al.

ACS APPLIED NANO MATERIALS (2018)

Review Cell Biology

Microfluidics-based on-a-chip systems for isolating and analysing extracellular vesicles

Shang-Chun Guo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

Review Biochemical Research Methods

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Jose C. Contreras-Naranjo et al.

LAB ON A CHIP (2017)

Article Multidisciplinary Sciences

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Sushrut Kamerkar et al.

NATURE (2017)

Article Multidisciplinary Sciences

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

Mengxi Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Medicine, Research & Experimental

Progress in Exosome Isolation Techniques

Pin Li et al.

THERANOSTICS (2017)

Article Chemistry, Multidisciplinary

The Exosome Total Isolation Chip

Fei Liu et al.

ACS NANO (2017)

Article Biochemistry & Molecular Biology

Qualitative differences in T-cell activation by dendritic cell-derived extracellular vesicle subtypes

Mercedes Tkach et al.

EMBO JOURNAL (2017)

Article Nanoscience & Nanotechnology

Chemically Edited Exosomes with Dual Ligand Purified by Microfluidic Device for Active Targeted Drug Delivery to Tumor Cells

Jie Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Cell Biology

Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

Rosario Maroto et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

Article Chemistry, Multidisciplinary

Rapid Isolation and Detection of Exosomes and Associated Biomarkers from Plasma

Stuart D. Ibsen et al.

ACS NANO (2017)

Review Cardiac & Cardiovascular Systems

Methodological Guidelines to Study Extracellular Vesicles

Frank A. W. Coumans et al.

CIRCULATION RESEARCH (2017)

Article Materials Science, Biomaterials

Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides

Randy P. Carney et al.

ADVANCED BIOSYSTEMS (2017)

Article Chemistry, Multidisciplinary

Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles

Yi-Ge Zhou et al.

SMALL (2016)

Review Chemistry, Multidisciplinary

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

Scott W. Ferguson et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Biochemical Research Methods

Real-time modulated nanoparticle separation with an ultra-large dynamic range

Kerwin Kwek Zeming et al.

LAB ON A CHIP (2016)

Article Nanoscience & Nanotechnology

Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm

Benjamin H. Wunsch et al.

NATURE NANOTECHNOLOGY (2016)

Article Chemistry, Analytical

Isolation of extracellular vesicle from blood plasma using electrophoretic migration through porous membrane

Siwoo Cho et al.

SENSORS AND ACTUATORS B-CHEMICAL (2016)

Article Chemistry, Multidisciplinary

A Single-Cell Assay for Time Lapse Studies of Exosome Secretion and Cell Behaviors

Yu-Jui Chiu et al.

SMALL (2016)

Article Cell Biology

Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer

Chang-Sook Hong et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

Article Chemistry, Multidisciplinary

Acoustic Purification of Extracellular Microvesicles

Kyungheon Lee et al.

ACS NANO (2015)

Article Biochemical Research Methods

Rapid inertial solution exchange for enrichment and flow cytometric detection of microvesicles

Jaideep S. Dudani et al.

BIOMICROFLUIDICS (2015)

Article Biochemical Research Methods

Recent advances in microfluidic actuation and micro-object manipulation via surface acoustic waves

Ghulam Destgeer et al.

LAB ON A CHIP (2015)

Article Biochemical Research Methods

Exosome isolation: a microfluidic road-map

A. Liga et al.

LAB ON A CHIP (2015)

Review Cell Biology

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

Emanuele Cocucci et al.

TRENDS IN CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

Huilin Shao et al.

NATURE COMMUNICATIONS (2015)

Article Cell Biology

Ready-made chromatography columns for extracellular vesicle isolation from plasma

Joanne Louise Welton et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Biochemical Research Methods

DLD pillar shape design for efficient separation of spherical and non-spherical bioparticles

Shashi Ranjan et al.

LAB ON A CHIP (2014)

Review Biochemical Research Methods

Deterministic lateral displacement for particle separation: a review

J. McGrath et al.

LAB ON A CHIP (2014)

Article Biochemical Research Methods

Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes

Shailender Singh Kanwar et al.

LAB ON A CHIP (2014)

Article Biotechnology & Applied Microbiology

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

Hyungsoon Im et al.

NATURE BIOTECHNOLOGY (2014)

Article Cell Biology

Comparative analysis of discrete exosome fractions obtained by differential centrifugation

Dennis K. Jeppesen et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

Article Cell Biology

Single-step isolation of extracellular vesicles by size-exclusion chromatography

Anita N. Boing et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

Review Chemistry, Multidisciplinary

Materials for Microfluidic Chip Fabrication

Kangning Ren et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

Review Chemistry, Multidisciplinary

Advances in Microfluidic Materials, Functions, Integration, and Applications

Pamela N. Nge et al.

CHEMICAL REVIEWS (2013)

Article Neurosciences

Quantification of human urinary exosomes by nanoparticle tracking analysis

Wilna Oosthuyzen et al.

JOURNAL OF PHYSIOLOGY-LONDON (2013)

Review Biochemical Research Methods

Surface acoustic wave microfluidics

Xiaoyun Ding et al.

LAB ON A CHIP (2013)

Article Biochemical Research Methods

Cell pairing using a dielectrophoresis-based device with interdigitated array electrodes

Mustafa Sen et al.

LAB ON A CHIP (2013)

Article Biochemical Research Methods

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

Zongxing Wang et al.

LAB ON A CHIP (2013)

Article Cell Biology

Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes

Rossella Crescitelli et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

Article Cell Biology

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Kenneth W. Witwer et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

Article Biochemical Research Methods

Microfluidic filtration system to isolate extracellular vesicles from blood

Ryan T. Davies et al.

LAB ON A CHIP (2012)

Review Biophysics

Dielectrophoretic platforms for bio-microfluidic systems

Khashayar Khoshmanesh et al.

BIOSENSORS & BIOELECTRONICS (2011)

Review Urology & Nephrology

Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases

Bas W. M. van Balkom et al.

KIDNEY INTERNATIONAL (2011)

Article Biochemical Research Methods

Microfluidic isolation and transcriptome analysis of serum microvesicles

Chihchen Chen et al.

LAB ON A CHIP (2010)

Article Physics, Multidisciplinary

Tunable nonlinear viscoelastic focusing in a microfluidic device

A. M. Leshansky et al.

PHYSICAL REVIEW LETTERS (2007)

Article Biochemical Research Methods

Critical particle size for fractionation by deterministic lateral displacement

DW Inglis et al.

LAB ON A CHIP (2006)

Article Multidisciplinary Sciences

Identification and proteomic profiling of exosomes in human urine

T Pisitkun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Pharmacology & Pharmacy

The use of asymmetrical flow field-flow fractionation in pharmaceutics and biopharmaceutics

W Fraunhofer et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2004)

Article Multidisciplinary Sciences

Continuous particle separation through deterministic lateral displacement

LR Huang et al.

SCIENCE (2004)