Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 336, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.129706
Keywords
Fiber optic; Localized surface plasmon resonance; Cytosensor; Gold nanoparticle coverage
Funding
- Natural Science Foundation of Shaanxi Province, China [2020JQ573]
- National Natural Science Foundation of China [21874095]
- Key Research and Development Program in Shaanxi Province of China [2019ZDLSF0103]
- Key Research and Development Project from Department of Science and Technology, Sichuan Province PR China [2017SZ0013]
- Innovation Spark Project of Sichuan University [2018SCUH0076]
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The study presented a novel LSPR-based cytosensor using Omega-shaped fiber optic with suitable AuNPs coverage, which showed high sensitivity and rapid detection for cancer cells, indicating promising applications in cancer diagnosis.
Cytosensor plays a vital role on the cancer diagnosis at early stage. Localized surface plasmon resonance (LSPR)based fiber optic is a type of emerging cytosensor with the merits of miniaturized devices, real-time and label-free detection, which is, however, limited by its low sensitivity and time-consuming analysis processes. To address those limitations, in this work a one-step LSPR-based cytosensor was constructed featuring Omega-shaped fiber optic with suitable AuNPs coverage. Both refractive index sensitivity (RIS) and density of captured cancer cells increased with a uniform AuNPs, while a sharp decrease of RIS and a plateau of density of captured cancer cells was found when AuNPs coverage increased at aggregation state. Under the same AuNPs coverage, the Omega-shaped fiber optic exhibited an enhanced RIS and efficiency of captured cancer cells, compared to the Ushaped fiber optic, which in hence led to a rapid and ultra-sensitive cytosensor based on Omega-shaped fiber optic cytosensor based on LSPR. The proposed cytosensor with suitable AuNPs coverage has a wide linear range of 5x10(1) similar to 1x10(5) cells/mL with low limit of detection (LOD) of 12 cells/mL for rapid detection of MCF-7 cancer cells just in 37.5 min. Noticeably, an excellent selectivity and anti-inference were achieved by the cytosensor even in fetal bovine serum. Thus, Omega-shaped fiber optic LSPR-based cytosensor has promising application as an analytical method for cancer diagnosis in the further.
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