Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 338, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.129841
Keywords
Pyroglutamate aminopeptidase 1; Near-infrared ratio fluorescence probe; Drug induced; Inflammatory factor; Tumor imaging
Funding
- Natural Science Foundation of China [21771092, 81903561]
- International Cooperation Program of Gansu Province [20YF3WA012]
- Fundamental Research Funds for the Central Universities [lzujbky2020kb13]
- Special Fund Project of Guiding Scientific and Technological Innovation Development of Gansu Province [2019ZX04]
- State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China
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Research has found that the designed probe TP-1 for PGP-1 detection is more accurate, revealing the association between PGP-1 and inflammation and tumors, providing important clues for further study of disease mechanisms.
Studies have found that there is overexpression of pyroglutamate aminopeptidase 1 (PGP-1) during inflammation, but the relationship between PGP-1 and disease is still unclear. To explore this situation, we designed the first near-infrared ratiometric fluorescence probe TP-1 for the PGP-1 specific detection to discuss the above problem. The large Stokes shift (?abs = 400 nm, ?em = 564 nm), high sensitivity and the lowest detection limit (0.14 ng/mL) make the detection of PGP-1 more accurate. HepG2 cells, RAW264.7 cells and mice are used to detect the relationship between the expression of PGP-1 and inflammation, and the expression of PGP-1 in different organs and tumors mice was explored for the first time. In vivo experiments have shown that in addition to the up-regulation of PGP-1 in inflammation, the expression of PGP-1 in tumor mice is more.
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