An electrochemical platform based on yttrium oxide/boron nitride nanocomposite for the detection of dopamine

Dopamine is an essential neurotransmitter for intercellular communication in the living organisms. Miniature sensors for dopamine detection, which rely on the electrochemical sensor with hybrid materials, cannot provide continuous monitoring and comes with several practical limits. High selectivity and sensitivity testified by human samples as well as low limit of detection are still challenging. This work reports the nanocomposite synthesis of yttrium oxide decorated on boron nitride (YO/BN) by a feasible sonochemical route for electrochemical detection of dopamine. Diverse microscopic and spectroscopic techniques are utilized to confirm the formation and the characteristics of the YO/BN nanocomposite. Compared to bare, YO- and BN-modified electrodes, the YO/BN modified electrode displays the superior electrochemical performance toward the detection of dopamine. Our electrochemical platform exhibits a wide linear range (0.008-241 mu M), low detection limit (0.0003 mu M) and high sensitivity (1.09 mu A mu M-1 cm(-2)) by the amperometric measurement. Furthermore, the proposed electrochemical sensor satisfies the clinical requirement in terms of reproducibility, selectivity, stability and recovery. The obtained results confirm that the proposed YO/BN based sensor can be used for the quantification analysis of dopamine in health management and clinical applications.

Automated summary

This study introduces a nanocomposite sensor for dopamine detection, utilizing yttrium oxide decorated boron nitride, demonstrating high sensitivity and low detection limit. The sensor shows superior electrochemical performance compared to other modified electrodes, making it suitable for quantification analysis of dopamine in health management and clinical applications.