Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 339, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.129852
Keywords
Electrochemical immunosensor; Reduced graphene oxide; Au nanoparticles; CEA; Signal amplifying
Funding
- National Natural Science Foundation of China [61571280, 61971274]
- Key Technology Research and Development Program of Shandong [2019GSF108253]
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A novel amperometric immunosensor was developed using ZnMn2O4@rGO composites to detect CEA, showing a broad linear detection range and low detection limit. The sensor demonstrated high sensitivity and specificity for monitoring CEA in clinical diagnosis, indicating its potential for use in tumor marker detection.
A novel amperometric immunosensor was designed and fabricated to sensitively detect carcinoembryonic antigen (CEA) using ZnMn2O4@reduced graphene oxide (ZnMn2O4@rGO) composites as signal amplifier. In this designed sensing platform, ZnMn2O4@rGO composites were facilely synthesized via a simple solvothermal process. The morphology and structure characteristics of composites were explored through scanning electron microscope, X-ray powder diffraction and X-ray photoelectron spectroscopy. The construction process of the immunosensor was monitored by cyclic voltammetry and A.C. impedance. The remarkable change in the electrocatalytic current of ZnMn2O4@rGO to H2O2 indicated the immunoreaction between antibody and CEA, resulting in sensitive detection of CEA with a broad linear range from 0.01 to 50 ng/mL (R2 = 0.9988) and a low detection limit of 1.93 pg/mL. Moreover, real human serum sample analysis demonstrated the availability of the immunosensor to monitor CEA as well as other tumor markers in clinical diagnosis.
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