Methamphetamine detection enabled by a fluorescent carborane derivative of perylene monoimide in film state

Rapid and on-site detection of illicit drugs in liquid phase remains a challenge for years. Herein, we report the synthesis of an o-carborane derivative of perylene monoimide (P MI-CBH) with high fluorescence quantum yield in solid state. The emission of the compound-based film is sensitive to the presence of methamphetamine (MAPA) in vapor phase with a detection limit (DL) lower than 1.4 ppb and a response time less than 2 s. With combination of liquid-liquid micro- extraction, the fluorescent film was successfully used for the detection of MAPA in aqueous phase including human urines even at a concentration lower than 1.0 mu g/mL. Further tests revealed that commonly used anti-cold drugs showed little effect upon the sensing. Moreover, the film is photochemically stable and reusable, demonstrating its potential for real-life applications.

Automated summary

The synthesis of a highly fluorescent P MI-CBH derivative enabled the creation of a sensitive film for the detection of methamphetamine in liquid phase, with a low detection limit and quick response time. The film was also shown to be stable, reusable, and effective for real-life applications, indicating its potential for practical use.