Journal
SENSORS
Volume 21, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/s21196326
Keywords
fluorescent probe; hypochlorite; bioimaging; sensitivity; reactive oxygen species (ROS)
Funding
- National Natural Science Foundation of China [21602103]
- Science and Technology Program of Guangzhou, China [202102010490]
- Guangzhou University [RP2021034]
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This review summarized the progress of recently discovered fluorescent probes for the detection of hypochlorous acid, aiming to provide useful information for further design of better fluorescent probes.
Hypochlorous acid (HOCl) generates from the reaction between hydrogen peroxide and chloride ions via myeloperoxidase (MPO)-mediated in vivo. As very important reactive oxygen species (ROS), hypochlorous acid (HOCl)/hypochlorite (OCl-) play a crucial role in a variety of physiological and pathological processes. However, excessive or misplaced production of HOCl/OCl- can cause variety of tissue damage and human diseases. Therefore, rapid, sensitive, and selective detection of OCl- is very important. In recent years, the fluorescent probe method for detecting hypochlorous acid has been developed rapidly due to its simple operation, low toxicity, high sensitivity, and high selectivity. In this review, the progress of recently discovered fluorescent probes for the detection of hypochlorous acid was summarized with the aim to provide useful information for further design of better fluorescent probes.
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