Journal
SENSORS
Volume 21, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/s21155185
Keywords
lateral flow immunoassay; lateral flow assay applications; paper-based biosensor; immunochromatographic strip test; rapid diagnostic test; point-of-care testing
Funding
- Ministry of Education, University and Research of Italy [PRIN: 2017Y2PAB8]
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LFIA is a successful analytical platform for on-site detection of target substances, with features like rapidity, simplicity, cost-effectiveness, and usability by nonskilled personnel. It is widely used in clinical diagnostic and other fields due to its wide acceptance. This review provides a 10-year overview of LFIA applications, discussing future perspectives and challenges.
The Lateral Flow Immunoassay (LFIA) is by far one of the most successful analytical platforms to perform the on-site detection of target substances. LFIA can be considered as a sort of lab-in-a-hand and, together with other point-of-need tests, has represented a paradigm shift from sample-to-lab to lab-to-sample aiming to improve decision making and turnaround time. The features of LFIAs made them a very attractive tool in clinical diagnostic where they can improve patient care by enabling more prompt diagnosis and treatment decisions. The rapidity, simplicity, relative cost-effectiveness, and the possibility to be used by nonskilled personnel contributed to the wide acceptance of LFIAs. As a consequence, from the detection of molecules, organisms, and (bio)markers for clinical purposes, the LFIA application has been rapidly extended to other fields, including food and feed safety, veterinary medicine, environmental control, and many others. This review aims to provide readers with a 10-years overview of applications, outlining the trends for the main application fields and the relative compounded annual growth rates. Moreover, future perspectives and challenges are discussed.
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