Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 26, Issue 4, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2021.101279
Keywords
Electroencephalogram; Neonate; Neonatal encephalopathy; Neonatal seizures; Anti-Seizure medication; Hypothermia treatment
Categories
Ask authors/readers for more resources
Neonatal encephalopathy is the most common cause of acute neonatal seizures, which should be identified through continuous EEG monitoring. The treatment goal is to minimize seizure burden and reduce the risk of brain injury.
Neonatal encephalopathy (NE) is the most common etiology of acute neonatal seizures - about half of neonates treated with therapeutic hypothermia for NE have EEG-confirmed seizures. These seizures are best identified with continuous EEG monitoring, as clinical diagnosis leads to under-diagnosis of subclinical seizures and overtreatment of events that are not seizures. High seizure burden, especially status epilepticus, is thought to augment brain injury. Treatment, therefore, is aimed at minimizing seizure burden. Phenobarbital remains the mainstay of treatment, as it is more effective than levetiracetam and easier to administer than fosphenytoin. Emerging evidence suggests that, for many neonates, it is safe to discontinue the phenobarbital after acute seizures resolve and prior to hospital discharge.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available