4.6 Review

Multigenerational epigenetic inheritance: Transmitting information across generations

Related references

Note: Only part of the references are listed.
Article Developmental Biology

Caenorhabditis elegans establishes germline versus soma by balancing inherited histone methylation

Brandon S. Carpenter et al.

Summary: The study demonstrates that in Caenorhabditis elegans, MES-4 protects key germline genes by preventing reprogramming, thus avoiding developmental delays.

DEVELOPMENT (2021)

Article Multidisciplinary Sciences

N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress

Qin-Li Wan et al.

Summary: Environmental stress can lead to survival advantages in descendants through transgenerational inheritance and epigenetic modifications.

SCIENCE ADVANCES (2021)

Article Cell Biology

Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring

Ariane Lismer et al.

Summary: This study demonstrates that a father's diet can alter the epigenome of sperm and embryos, affecting gene expression and developmental outcomes in offspring. Paternal epigenetic errors transmitted through sperm may accumulate and worsen developmental defects in offspring.

DEVELOPMENTAL CELL (2021)

Article Biology

Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis

Pedro Robles et al.

Summary: Environmental stimuli experienced by the parental generation can influence the phenotype of subsequent generations through the germline. Metabolic sensors regulate phenotypic plasticity by modulating the subcellular localization of their effectors, leading to changes in chromatin acetylation and epigenetic status of the germline.

BMC BIOLOGY (2021)

Article Genetics & Heredity

H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos

Hailiang Mei et al.

Summary: The study reveals the preceding dynamics of H2AK119ub1 over H3K27me3 at the maternal-to-zygotic transition, and identifies PCGF1/6-vPRC1 as an essential player in maternal epigenetic inheritance.

NATURE GENETICS (2021)

Article Genetics & Heredity

Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos

Zhiyuan Chen et al.

Summary: In mouse preimplantation embryos, H2AK119ub1 and H3K27me3 have distinct genome-wide dynamics. Loss of H2AK119ub1 results in premature activation of developmental genes, while loss of H3K27me3 does not.

NATURE GENETICS (2021)

Article Multidisciplinary Sciences

A parental transcriptional response to microsporidia infection induces inherited immunity in offspring

Alexandra R. Willis et al.

Summary: Parental infection can result in offspring with enhanced immunity, as shown in Caenorhabditis elegans infected with N. parisii. The offspring's immunity is induced by the parental transcriptional response to infection, protecting them against multiple classes of pathogens.

SCIENCE ADVANCES (2021)

Article Biochemistry & Molecular Biology

Neuronal perception of the social environment generates an inherited memory that controls the development and generation time of C. elegans

Marcos Francisco Perez et al.

Summary: Research shows that chemical pheromones in the social environment can be transmitted across generations through sensory neurons, significantly impacting the timing of offspring development.

CURRENT BIOLOGY (2021)

Article Multidisciplinary Sciences

Natural cryptic variation in epigenetic modulation of an embryonic gene regulatory network

Chee Kiang Ewe et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection

Nicholas O. Burton et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA

Ziyang Hao et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

No evidence for DNA N-6-methyladenine in mammals

Karolos Douvlataniotis et al.

SCIENCE ADVANCES (2020)

Article Multidisciplinary Sciences

poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

Aditi Shukla et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

Leah Houri-Zeevi et al.

Article Multidisciplinary Sciences

C. elegansinterprets bacterial non-coding RNAs to learn pathogenic avoidance

Rachel Kaletsky et al.

NATURE (2020)

Article Multidisciplinary Sciences

Prenatal and early-life exposure to the Great Chinese Famine increased the risk of tuberculosis in adulthood across two generations

Qu Cheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Biochemistry & Molecular Biology

Genomic Imprinting and Physiological Processes in Mammals

Valter Tucci et al.

Article Multidisciplinary Sciences

Sperm-inherited H3K27me3 impacts offspring transcription and development in C. elegans

Kiyomi Raye Kaneshiro et al.

NATURE COMMUNICATIONS (2019)

Article Biology

Revisiting mechanisms and functions of prenatal hormone-mediated maternal effects using avian species as a model

Ton G. G. Groothuis et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance

Rebecca S. Moore et al.

Article Biochemistry & Molecular Biology

Neuronal Small RNAs Control Behavior Transgenerationally

Rachel Posner et al.

Article Biochemistry & Molecular Biology

Insulin/IGF Signaling and Vitellogenin Provisioning Mediate Intergenerational Adaptation to Nutrient Stress

James M. Jordan et al.

CURRENT BIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA

Zach K. O'Brown et al.

BMC GENOMICS (2019)

Review Cell Biology

Intergenerational and transgenerational epigenetic inheritance in animals

Marcos Francisco Perez et al.

NATURE CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila

Maria Clara Guida et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Rapid evolution and conserved function of the piRNA pathway

Swapnil S. Parhad et al.

OPEN BIOLOGY (2019)

Article Cell Biology

DNA N 6 -Adenine Methylation in Arabidopsis thaliana

Zhe Liang et al.

DEVELOPMENTAL CELL (2018)

Review Cell Biology

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition

Melanie A. Eckersley-Maslin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Cell Biology

A Cytoplasmic Argonaute Protein Promotes the Inheritance of RNAi

Fei Xu et al.

CELL REPORTS (2018)

Article Cell Biology

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm

Upasna Sharma et al.

DEVELOPMENTAL CELL (2018)

Article Multidisciplinary Sciences

Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

Gang Wan et al.

NATURE (2018)

Article Multidisciplinary Sciences

The relationship between transgenerational acquired resistance and global DNA methylation in Arabidopsis

Joost H. M. Stassen et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis

Tomoko M. Tabuchi et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

Genomic imprinting of Xist by maternal H3K27me3

Azusa Inoue et al.

GENES & DEVELOPMENT (2017)

Article Genetics & Heredity

The RNAi Inheritance Machinery of Caenorhabditis elegans

George Spracklin et al.

GENETICS (2017)

Article Multidisciplinary Sciences

Maternal age generates phenotypic variation in Caenorhabditis elegans

Marcos Francisco Perez et al.

NATURE (2017)

Article Multidisciplinary Sciences

Maternal H3K27me3 controls DNA methylation-independent imprinting

Azusa Inoue et al.

NATURE (2017)

Article Cell Biology

Insulin-like signalling to the maternal germline controls progeny response to osmotic stress

Nicholas O. Burton et al.

NATURE CELL BIOLOGY (2017)

Article Genetics & Heredity

Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

Filippo Ciabrelli et al.

NATURE GENETICS (2017)

Article Multidisciplinary Sciences

Ecdysone signaling underlies the pea aphid transgenerational wing polyphenism

Neetha Nanoth Vellichirammal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Transgenerational transmission of environmental information in C-elegans

Adam Klosin et al.

SCIENCE (2017)

Review Multidisciplinary Sciences

The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity

Christina Ernst et al.

NATURE COMMUNICATIONS (2017)

Article Genetics & Heredity

The RNAi Inheritance Machinery of Caenorhabditis elegans

George Spracklin et al.

GENETICS (2017)

Article Chemistry, Multidisciplinary

Quantitative LC-MS Provides No Evidence for m6dA or m4dC in the Genome of Mouse Embryonic Stem Cells and Tissues

Sarah Schiffers et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemistry & Molecular Biology

MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance

Itamar Lev et al.

CURRENT BIOLOGY (2017)

Article Cell Biology

Mutation of C. elegans demethylase spr-5 extends transgenerational longevity

Eric Lieberman Greer et al.

CELL RESEARCH (2016)

Article Biochemistry & Molecular Biology

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications

Magdalena J. Koziol et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications

Magdalena J. Koziol et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Transgenerational epigenetic inheritance in mammals: how good is the evidence?

Sanne D. van Otterdijk et al.

FASEB JOURNAL (2016)

Article Genetics & Heredity

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

Peter Huypens et al.

NATURE GENETICS (2016)

Review Genetics & Heredity

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

Qi Chen et al.

NATURE REVIEWS GENETICS (2016)

Article Multidisciplinary Sciences

Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

Jianzhao Liu et al.

NATURE COMMUNICATIONS (2016)

Article Endocrinology & Metabolism

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

Thais de Castro Barbosa et al.

MOLECULAR METABOLISM (2016)

Review Biochemistry & Molecular Biology

I'm Eating for Two: Parental Dietary Effects on Offspring Metabolism

Oliver J. Rando et al.

Article Biochemistry & Molecular Biology

DNA Methylation on N6-Adenine in C-elegans

Eric Lieberman Greer et al.

Article Biochemistry & Molecular Biology

N6-Methyladenine DNA Modification in Drosophila

Guoqiang Zhang et al.

Article Multidisciplinary Sciences

Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress

Ali B. Rodgers et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Genetics & Heredity

Tertiary siRNAs Mediate Paramutation in C. elegans

Alexandra Sapetschnig et al.

PLOS GENETICS (2015)

Article Biochemistry & Molecular Biology

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

Anita Ost et al.

Article Biochemistry & Molecular Biology

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

Oded Rechavi et al.

Review Biochemistry & Molecular Biology

Ancient Endo-siRNA Pathways Reveal New Tricks

Julie M. Claycomb

CURRENT BIOLOGY (2014)

Review Obstetrics & Gynecology

Transgenerational developmental programming

Catherine E. Aiken et al.

HUMAN REPRODUCTION UPDATE (2014)

Article Multidisciplinary Sciences

SPR-5 and MET-2 function cooperatively to reestablish an epigenetic ground state during passage through the germ line

Shana C. Kerr et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

Elizabeth J. Radford et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

H3K27me and PRC2 transmit a memory of repression across generations and during development

Laura J. Gaydos et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Mapping the Epigenetic Basis of Complex Traits

Sandra Cortijo et al.

SCIENCE (2014)

Review Immunology

Insights from the worm: The C. elegans model for innate immunity

Maria A. Ermolaeva et al.

SEMINARS IN IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

Natural RNA interference directs a heritable response to the environment

Daniel Schott et al.

SCIENTIFIC REPORTS (2014)

Review Biochemistry & Molecular Biology

X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease

Jeannie T. Lee et al.

Article Ecology

Weak evidence for anticipatory parental effects in plants and animals

T. Uller et al.

JOURNAL OF EVOLUTIONARY BIOLOGY (2013)

Article Biochemistry & Molecular Biology

C. elegans piRNAs Mediate the Genome-wide Surveillance of Germline Transcripts

Heng-Chi Lee et al.

Article Biochemistry & Molecular Biology

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

Alyson Ashe et al.

Article Biochemistry & Molecular Biology

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

Svetlana Petruk et al.

Article Biochemistry & Molecular Biology

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

Masaki Shirayama et al.

Article Biochemistry & Molecular Biology

Reprogramming of DNA Methylation in Pollen Guides Epigenetic Inheritance via Small RNA

Joseph P. Calarco et al.

Article Multidisciplinary Sciences

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

Bethany A. Buckley et al.

NATURE (2012)

Article Multidisciplinary Sciences

Paramutation in Drosophila linked to emergence of a piRNA-producing locus

Augustin de Vanssay et al.

NATURE (2012)

Article Plant Sciences

Next-Generation Systemic Acquired Resistance

Estrella Luna et al.

PLANT PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

Ki-Hyeon Seong et al.

Article Biochemistry & Molecular Biology

Mechanisms for the Inheritance of Chromatin States

Danesh Moazed

Article Biochemistry & Molecular Biology

PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression

Eerappa Rajakumara et al.

MOLECULAR CELL (2011)

Article Multidisciplinary Sciences

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Eric L. Greer et al.

NATURE (2011)

Article Multidisciplinary Sciences

Spontaneous epigenetic variation in the Arabidopsis thaliana methylome

Claude Becker et al.

NATURE (2011)

Article Multidisciplinary Sciences

Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans

Nick O. Burton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells

Yu Xiao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Transgenerational Epigenetic Instability Is a Source of Novel Methylation Variants

Robert J. Schmitz et al.

SCIENCE (2011)

Article Cell Biology

Small Noncoding RNAs in the Germline

Jonathan P. Saxe et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Review Nutrition & Dietetics

Folic Acid Food Fortification-Its History, Effect, Concerns, and Future Directions

Krista S. Crider et al.

NUTRIENTS (2011)

Article Biochemistry & Molecular Biology

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

Till Bartke et al.

Article Biochemistry & Molecular Biology

Methylation of H3K4 Is Required for Inheritance of Active Transcriptional States

Tetsuya Muramoto et al.

CURRENT BIOLOGY (2010)

Article Multidisciplinary Sciences

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Sheau-Fang Ng et al.

NATURE (2010)

Article Multidisciplinary Sciences

RNA-mediated trans-communication can establish paramutation at the b1 locus in maize

Mario Arteaga-Vazquez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro

Nicole J. Francis et al.

Article Multidisciplinary Sciences

Selective epigenetic control of retrotransposition in Arabidopsis

Marie Mirouze et al.

NATURE (2009)

Article Genetics & Heredity

Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits

Frank Johannes et al.

PLOS GENETICS (2009)

Article Physiology

Maternal obesity at conception programs obesity in the offspring

Kartik Shankar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2008)

Article Multidisciplinary Sciences

Intersection of the RNA interference and X-inactivation pathways

Yuya Ogawa et al.

SCIENCE (2008)

Review Ecology

Developmental plasticity and the evolution of parental effects

Tobias Uller

TRENDS IN ECOLOGY & EVOLUTION (2008)

Review Ecology

Maternal transfer of antibodies: raising immuno-ecology issues

Thierry Boulinier et al.

TRENDS IN ECOLOGY & EVOLUTION (2008)

Article Biochemistry & Molecular Biology

Paramutation: From maize to mice

Vicki L. Chandler

Article Biochemistry & Molecular Biology

The SRA methyl-cytosine-binding domain links DNA and histone methylation

Lianna M. Johnson et al.

CURRENT BIOLOGY (2007)

Article Obstetrics & Gynecology

The Dutch famine and its long-term consequences for adult health

Tessa Roseboom et al.

EARLY HUMAN DEVELOPMENT (2006)

Article Biochemistry & Molecular Biology

Arabidopsis displays centromeric DNA hypomethylation and cytological alterations of heterochromatin upon attack by Pseudomonas syringae

Valeria Pavet et al.

MOLECULAR PLANT-MICROBE INTERACTIONS (2006)

Article Multidisciplinary Sciences

RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse

Minoo Rassoulzadegan et al.

NATURE (2006)

Article Environmental Sciences

Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome

DC Dolinoy et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2006)

Article Nutrition & Dietetics

Developmental programming of health and disease

SC Langley-Evans

PROCEEDINGS OF THE NUTRITION SOCIETY (2006)

Article Multidisciplinary Sciences

An antiviral role for the RNA interference machinery in Caenorhabditis elegans

DH Schott et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Cell Biology

DNA methylation and histone modifications: teaming up to silence genes

F Fuks

CURRENT OPINION IN GENETICS & DEVELOPMENT (2005)

Article Reproductive Biology

Prenatal exposure to the Dutch famine and disease in later life: An overview

RC Painter et al.

REPRODUCTIVE TOXICOLOGY (2005)

Article Multidisciplinary Sciences

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production

T Sugiyama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans

BBJ Tops et al.

NUCLEIC ACIDS RESEARCH (2005)

Article Multidisciplinary Sciences

RNAi-mediated targeting of heterochromatin by the RITS complex

A Verdel et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

F Fuks et al.

NUCLEIC ACIDS RESEARCH (2003)

Article Multidisciplinary Sciences

Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission

VK Rakyan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Role of histone H3 lysine 27 methylation in polycomb-group silencing

R Cao et al.

SCIENCE (2002)

Article Biochemistry & Molecular Biology

Histone methyltransferase activity of a Drosophila polycomb group repressor complex

J Müller et al.

Article Developmental Biology

Epigenetic reprogramming in mouse primordial germ cells

P Hajkova et al.

MECHANISMS OF DEVELOPMENT (2002)

Article Biochemistry & Molecular Biology

On the role of RNA amplification in dsRNA-triggered gene silencing

T Sijen et al.

Article Endocrinology & Metabolism

Intrauterine growth retardation leads to the development of type 2 diabetes in the rat

RA Simmons et al.

DIABETES (2001)

Article Multidisciplinary Sciences

Genetic requirements for inheritance of RNAi in C-elegans

A Grishok et al.

SCIENCE (2000)