Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 126, Issue -, Pages 15-26Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2021.07.008
Keywords
Circadian clock; Metabolism; Sirtuins; Aging; Nicotinamide adenine dinucleotide(NAD plus )
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01DK090625, R01DK100814, 1R01DK113011-01A1]
- Chicago Biomedical Consortium [S-007]
- National Institute on Aging (NIA) [P01AG011412]
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Intrinsic circadian clocks regulate daily anticipation of light/dark cycles and energy storage/utilization cycles. Disruption of the core clock can contribute to disease. Peripheral clocks can be influenced by metabolic cues. NAD(P)(H) nucleotides and NAD+-dependent sirtuin deacetylases play a key role in integrating circadian and metabolic cycles.
Intrinsic circadian clocks are present in all forms of photosensitive life, enabling daily anticipation of the light/ dark cycle and separation of energy storage and utilization cycles on a 24-h timescale. The core mechanism underlying circadian rhythmicity involves a cell-autonomous transcription/translation feedback loop that in turn drives rhythmic organismal physiology. In mammals, genetic studies have established that the core clock plays an essential role in maintaining metabolic health through actions within both brain pacemaker neurons and peripheral tissues and that disruption of the clock contributes to disease. Peripheral clocks, in turn, can be entrained by metabolic cues. In this review, we focus on the role of the nucleotide NAD(P)(H) and NAD+dependent sirtuin deacetylases as integrators of circadian and metabolic cycles, as well as the implications for this interrelationship in healthful aging.
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