Journal
SEMINARS IN CANCER BIOLOGY
Volume 82, Issue -, Pages 3-10Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2021.07.010
Keywords
Breast cancer; Tumor heterogeneity; Single-cell; Spatial pathology; Tumor microenvironment
Categories
Funding
- National Cancer Institute [CA148761, CA016303]
- Cancer Prevention and Research Institute of Texas [RP170172]
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Breast cancer ecosystems are complex, and understanding their heterogeneity through single-cell analysis and spatial pathologies can lead to the development of novel therapies and improved outcomes.
Breast cancer ecosystems are composed of complex cell types, including tumor, stromal and immune cells, each of which can assume diverse phenotypes. Both the heterogeneous composition and spatially distinct tumor microenvironment impact breast cancer progression, treatment response and therapeutic resistance. Thus, a deeper understanding of breast cancer heterogeneity may help facilitate the development of novel therapies and improve outcomes for patients. The advent of paradigm shifting single-cell analysis and spatial pathologies allows for a comprehensive analysis of the tumor ecosystem as well as the interactions between its components at unprecedented resolution. In this review, we discuss the insights gained through single-cell analysis and spatial pathologies on breast cancer heterogeneity.
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