Outside in and brakes off for lymphatic growth

In this issue of Science Signaling, Kataru et al. did two simple but powerful tweaks to the typical studies that aim to advance our understanding of proangiogenic interventions. They shifted the focus from the outside of the endothelial cell to the inside, and they chose not to deliver an angiogenic signal, but instead to release the brakes from an already existing signal.

Automated summary

In this study, Kataru et al. made two simple yet powerful adjustments to the typical approaches in studying proangiogenic interventions. By shifting the focus and releasing brakes from an existing signal, they were able to gain insightful results.