Emerging roles of PLCγ1 in endothelial biology

Phospholipase C gamma 1 (PLC gamma 1) is a member of the PLC family that functions as signal transducer by hydrolyzing membrane lipid to generate second messengers. The unique protein structure of PLC gamma 1 confers a critical role as a direct effector of VEGFR2 and signaling mediated by other receptor tyrosine kinases. The distinct vascular phenotypes in PLC gamma 1-deficient animal models and the gain-of-function mutations of PLC gamma 1 found in human endothelial cancers point to a major physiological role of PLC gamma 1 in the endothelial system. In this review, we discuss aspects of physiological and molecular function centering around PLC gamma 1 in the context of endothelial cells and provide a perspective for future investigation.

Automated summary

PLC gamma 1, a member of the PLC family, plays a crucial role as a signal transducer by hydrolyzing membrane lipid to generate second messengers. Deficiency of PLC gamma 1 in animal models and gain-of-function mutations in human endothelial cancers highlight its significant physiological role in the endothelial system. Understanding the physiological and molecular functions of PLC gamma 1 can provide insights for future research in the context of endothelial cells.