Fecal microbiota transplantation attenuates nano-plastics induced toxicity in Caenorhabditis elegans

Current studies simply focus on the toxicity of nano-plastics, while the correlation between their toxicity and biodistribution, as well as intestinal microorganisms is still blank. Therefore, we systematically evaluated the toxicity based on the accumulation characteristics of nano-plastics in C. elegans. Meanwhile, for the first time, human fecal microbiota was transplanted into the gut of C. elegans and found that nano-plastics can through the intestinal barrier to the whole body after oral intake and can't be drastically excreted until die, thus causing toxic effects; while human fecal microbiota transplantation can significantly improve the living state via activating PMK-1/SKN-1 pathway to promote the production of intracellular glutathione, and exogenous glutathione addition can also markedly protect nematodes against nano-plastics induced toxicity. Our results not only provide a fully understand between the accumulation characteristic and health risk of nano-plastics, but also take C. elegans and intestinal flora into the field of toxicity evolution of nanomaterials. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

This study systematically evaluated the toxicity of nano-plastics on C. elegans, and found that human fecal microbiota transplantation can alleviate the toxic effects through activating specific pathways.