Journal
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
Volume 81, Issue 6, Pages 451-453Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00365513.2021.1943758
Keywords
Hypersensitivity pneumonitis; antigen-specific IgG; Aspergillus fumigatus; moulds
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The study examined the relationship between sIgG antibodies against Aspergillus fumigatus and the diagnosis of hypersensitivity pneumonitis (HP), revealing that elevated levels of antibodies are associated with an increased risk of HP.
Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) caused by the inhalation of antigens. Antigen-specific IgG antibodies (sIgG) are used as biomarkers of exposure when diagnosing HP, but little is known about the longitudinal relation between antibody levels and risk of HP or other ILD. In a follow-up design, we explored the relationship between sIgG antibodies against Aspergillus fumigatus and the diagnosis of HP in 647 subjects suspected of HP. We showed that IgG levels above the reference value resulted in a hazard ratio of 9.5 for subsequent HP. Our findings support a relationship between high levels of sIgG against A. fumigatus and risk of HP.
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