Palladium(II) Complexes with Catecholamines: Synthesis and In Vitro Cytotoxic Activity

The reactions of palladium(II) chloride with catecholamines (hydrochlorides of 3-methoxytyramine, normetanephrine, norepinephrine, and dopamine) and pyridine-2-carbaldehyde have afforded four new palladium complexes of different types (pyridine-imine, oxazolidine-imine, and cation-anionic ones). Structure of the obtained complexes have been confirmed by means of NMR spectroscopy and X-ray diffraction analysis. Cytotoxic activity of the complexes with respect to PC3 (prostate cancer cells) and HEK-293 (human epithelial kidney cells) cell lines has been estimated.

Automated summary

This study investigated the structures and cytotoxic activities of four new palladium complexes obtained from the reactions of palladium(II) chloride with catecholamine salts and pyridine-2-carbaldehyde. The structure of the complexes was confirmed using NMR spectroscopy and X-ray diffraction analysis. The cytotoxic activity of the complexes on prostate cancer cells (PC3) and human epithelial kidney cells (HEK-293) was evaluated.