Journal
REPRODUCTIVE SCIENCES
Volume 28, Issue 10, Pages 2887-2894Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s43032-021-00640-0
Keywords
Hysterosalpingography; Oil-soluble iodinated contrast; Iodine excess; Pregnancy; Lactation
Categories
Funding
- Fundamental Research Funds for the Central Universities [3332018014]
- Project of Science and Technology of Beijing [Z191100008619006]
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The study found that preconceptional exposure to oil-based iodinated contrast may have far-reaching effects on the iodine status of pregnant women and their offspring, and may increase the risk of maternal thyroid dysfunction.
The objective of this study is to investigate the impact of preconceptional exposure to oil-based iodinated contrast in the hysterosalpingography (HSG) on pregnant women and their offspring's iodine status, thyroid function, and the outcomes of pregnancy. A cross-sectional evaluation of iodine status was performed on pregnant women with the preconceptional experience of ethiodized-oil HSG. For those found to have iodine excess (with serum iodine concentration (SIC) > 92 mu g/L), a prospective follow-up was conducted until termination of the pregnancy or 1 week postpartum. Among 70 of 425 pregnant women with preconceptional ethiodized-oil HSG, iodine excess was initially confirmed in 38 (54.3%), with an elevated SIC (294.00 mu g/L [142.00, 123.20]) and urinary iodine-to-creatinine ratio (UI/Cr) (830.00 mu g/g Cr [437.50, 255.30]), both higher than the normative data (P = 0.000, P = 0.000). Subsequent follow-up in pregnancy showed a downward trend in both SIC and UI/Cr. Thirty-four women delivered healthy neonates at full term, though the other 4 cases of premature birth, abnormal fetal karyotype, spontaneous abortion, and neonatal cardiac defect were reported. After delivery, the iodine concentration in maternal breast milk and neonatal urine was 584.50 mu g/L [328.50, 1507.50] and 424.00 mu g/L [277.00, 657.50], respectively, both higher than normative data (P = 0.001, P = 0.015). For thyroid evaluation, 25 cases (65.79%) of clinical or subclinical hypothyroidism and 2 cases (5.26%) of thyrotoxicosis were confirmed in women with iodine excess. Neither goiter nor thyroid dysfunction was detected in any offspring. Preconceptional exposure to oil-based contrast in HSG might exert a far-reaching impact on maternal and offspring iodine status, and tend to result in increased risk of maternal thyroid dysfunction.
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