Journal
REACTIVE & FUNCTIONAL POLYMERS
Volume 165, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.reactfunctpolym.2021.104955
Keywords
Polysaccharides; Physical assemblies; Biomaterials; Drug delivery systems
Funding
- CAPES agency
- National Council for Scientific and Technological Development - CNPq [0008678964988973]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [001]
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Thermo- and pH-sensitive hydrogels based on chitosan and gellan gum were developed for efficient curcumin delivery. The hydrogel structure containing 40-80% chitosan exhibited significant release of curcumin in simulated intestinal fluid.
Thermo- and pH-sensitive hydrogels based on chitosan (CS) and gellan gum (GG) were used for efficient curcumin (CUR) delivery for the first time. beta-Cyclodextrin/curcumin (beta CD/CUR) inclusion complex was mixed with aqueous GG solution and associated with CS solution aliquots. CS/GG hydrogels incorporated with the beta CD-CUR inclusion complex containing CS between 40 and 80 wt% were prepared by cooling CS/GG/beta CD/CUR mixtures. The materials were characterized by infrared spectroscopy, thermal analysis, X-ray diffraction, scanning electron microscopy, confocal scanning microscopy, and mechanical measurements. The CS/GG-beta CD-CUR ratio in the mixture significantly influenced the hydrogel properties. The pH-responsive hydrogels presented porosity between 76 and 84%, mechanical strength between 247 and 747 Pa, and disintegration rate lower than 25% in simulated intestinal fluid (SIF). The CUR release was investigated in simulated intestinal (SIF) and simulated gastric (SGF) fluids with and without lysozyme (27.8 mu g/mL) and Tween 80 (1% v/v). Lysozyme and Tween 80 enhanced the CUR release in SIF, reaching 69.40% (10.10 mg/g) after 240 h. The Ritger-Peppas and Higuchi mathematical models adjusted well to the experimental CUR release kinetic curves. The materials were cytocompatible toward healthy VERO cells. This study reports durable polysaccharide-based assemblies for CUR delivery created following a method in-situ.
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