Journal
RARE METALS
Volume 41, Issue 1, Pages 56-66Publisher
NONFERROUS METALS SOC CHINA
DOI: 10.1007/s12598-021-01795-0
Keywords
Photothermal; Phototherapy; Near-infrared dye; Photoinduced-electron transfer; Intramolecular charge transfer
Funding
- Natural Science Foundation of Jiangsu Province [BK20200092, BK20200710]
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The development of pH-sensitive NIR dye BTN with robust photothermal conversion efficiency and lysosome-targeting capability, fabricated as NPs with amphiphilic polymers, demonstrates outstanding imaging-guided photothermal therapy for tumor ablation in tumor-bearing nude mice.
To develop smart and efficient near-infrared (NIR) organic dyes for photothermal cancer therapy is of great challenge. Herein, a pH-sensitive NIR dye BTN with donor-acceptor-donor scaffold has been synthesized. Two periphery electron-donating dimethylamine groups in BTN can not only promote the intramolecular photoinduced electron transfer (PET), but also bind protons to transform into electron-deficient ammonium cation for enhanced intramolecular charge transfer (ICT) under acidic circumstance. Through enveloping with amphiphilic polymeric 1,2-distearoyl-ras-glycerol-3-phosphatidyl ethanolamine-N-polyethyleneglycol-2000 (DSPE-mPEG(2000)), BTN nanoparticles (NPs) were fabricated with robust NIR absorption covering 600-900 nm, excellent photothermal conversion efficiency (43.2%), and good photostability. Additionally, BTN NPs can selectively target lysosomes. Through tailing intravenous injection into tumor-bearing nude mice, BTN NPs demonstrate outstanding photoacoustic/photothermal/fluorescence imaging-guided photothermal therapy for tumor ablation. Graphic abstract
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