Journal
RARE METALS
Volume 41, Issue 2, Pages 689-699Publisher
NONFERROUS METALS SOC CHINA
DOI: 10.1007/s12598-021-01808-y
Keywords
Titanium; Plasma-based technology; Fluorine; Antibacterial property; Cytocompatibility
Funding
- National Natural Science Foundation of China [52001122, 51801064, 51961012]
- Jiangxi Outstanding Young Talents Program [20192BCB23014]
- Jiangxi Key Research and Development Program [20203BBE53050]
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This study investigated the different fluorine chemical compositions on titanium surfaces, demonstrating that coatings composed of metal fluorides exhibited superior antibacterial effect and cell compatibility. This provides a new perspective for optimizing surface modification methods of fluorinated biomaterials for biomedical applications.
Biomaterial surfaces with satisfied antibacterial activity and appropriate cytocompatibility are a pressing clinical need for orthopedic and dental implants. Fluorine-containing biomaterials have been demonstrated to obtain antibacterial activity and osteogenic property, while the effect of fluorine chemical compositions on antibacterial property and cytocompatibility is rarely studied. To this end, the coatings with different fluorine chemical compositions on titanium surface were prepared by plasma treatment to verify the antibacterial ability and cytocompatibility of fluorinated surfaces. Their antibacterial ability was evaluated by using Staphylococcus aureus, and the cell compatibility was investigated with MC3T3-E1 cells in vitro. The results show that both fluorocarbon coating and metal fluorides coating exhibited a hydrophilic and nano-scaled roughness. Rather than the fluorocarbon coating, the coating composed of metal fluorides presented satisfied bactericide effect and excellent cytocompatibility. The antibacterial mechanism is associated with the metal fluorides and released fluoride ion. This work would provide novel sight in optimizing the surface modification method of fluorinated biomaterials for biomedical applications.
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